Press

Press Release Archive

Aging | Krill Oil Protects Dopaminergic Neurons From Age-Related Degeneration Through Temporal Transcriptome Rewiring and Suppression of Several Hallmarks of Aging

11-22-2022

“Thus, krill oil supplementation might serve as a possible approach for healthy brain aging interventions.”

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BUFFALO, NY- November 22, 2022 – A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volu…

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Aging | The Deubiquitylase USP7 is a Novel Cyclin F-Interacting Protein and Regulates Cyclin F Protein Stability

11-21-2022

“This study highlights a potential role for the cyclin F-USP7 axis in pathological conditions, including cancer and neurodegenerative diseases.”

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BUFFALO, NY- November 21, 2022 – A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed …

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Aging | IGF1 Gene Therapy in Middle-Aged Female Rats Delays Reproductive Senescence Through Effects on Hypothalamic GnRH and Kisspeptin Neurons

11-15-2022

“Based on our findings, we propose IGF1 gene therapy to delay reproductive senescence as a potential strategy to optimize lifespan and combat age-related health problems in women.”

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BUFFALO, NY- November 15, 2022 – A new research paper was published on the cover of Aging

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Aging | Age-Associated Changes in Microglia Activation and Sirtuin-1- Chromatin Binding Patterns

11-10-2022

“This work suggests that preservation of microglia and Sirt1 binding activity and patterns, as well as the directionality of pathways regulated by Sirt1, are prognostic of long-living.”

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BUFFALO, NY- November 10, 2022 – A new research paper was published in Aging (listed …

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Aging | Lamin A to Z in Normal Aging

11-09-2022

“It has long been debated to what extent the mechanisms of aging and progeria overlap.”

BUFFALO, NY- November 9, 2022 – A new research perspective was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 20, entitled, “Lamin A to Z in normal aging.”

Almos…

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Aging’s Scientific Integrity Process

11-08-2022

The open-access journal Aging recently launched a new webpage showcasing the full Aging Scientific Integrity Process.

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BUFFALO, NY-November 8, 2022 – Scientific integrity is a crucial component of scholarly publishing for any credible journal. Peer-reviewed, open-access …

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Aging | Rapamycin Treatment Early in Life Reprograms Aging: Hyperfunction Theory and Clinical Practice

11-03-2022

“In conclusion, the rate of aging can be decelerated by using rapamycin during the early developmental growth phase. This has important theoretical significance but cannot be implemented in humans.”

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BUFFALO, NY- November 3, 2022 – A new research perspective was published …

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Aging | Downregulation of Senescence-Associated Secretory Phenotype by Knockdown of Secreted Frizzled-Related Protein 4 Contributes to Prevention of Skin Aging

10-31-2022

“Overall, this research could potentially aid in the development of anti-aging treatments for skin by preventing age-related changes through the regulation of SFRP4 expression in aging cells.”

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BUFFALO, NY- October 31, 2022 – A new research paper was published on the …

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Aging | RNA Modifications in Aging-Associated Cardiovascular Diseases

10-25-2022

“This review attempted to consolidate different aspects of RNA modifications that are crucial in regulating aging-associated CVDs.”

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BUFFALO, NY- October 26, 2022 – A new review paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" …

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Aging | Centenarians Consistently Present Younger Epigenetic Age Than Their Chronological Age With Four Epigenetic Clocks Based on Small Number of CpG Sites

10-17-2022

“To our knowledge, this is the first time that DNAmage was investigated in such a large cohort of centenarians and of long-lived individuals’ offspring using epigenetic clocks based on a small number of CpG sites [30–32].”

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BUFFALO, NY- October 17, 2022 – A new research …

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Aging | Psychological Factors Substantially Contribute to Biological Aging: Evidence From the Aging Rate in Chinese Older Adults

10-03-2022

“We used the aging clock to demonstrate the connection between the physical and psychological aspects of aging”

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BUFFALO, NY- October 3, 2022 – A new research paper was published on the cover of Aging (listed as "Aging (Albany NY)" by Medline/PubMed and "Aging-US" by Web …

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Aging | Probiotics Treatment for Parkinson Disease: A Systematic Review and Meta-analysis of Clinical Trials

09-27-2022

“The present study provides evidence for the prescription of probiotics for PwP [people with Parkinson’s disease], especially for their GI symptoms.”

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BUFFALO, NY- September 27, 2022 – A new research paper was published in Aging (listed as “Aging (Albany NY)” by …

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Aging | Aging, Prevalence and Risk Factors of MRI-visible Enlarged Perivascular Spaces

09-22-2022

“Severe ePVS prevalence increased with age in men and women [...]”

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BUFFALO, NY- September 22, 2022 – A new research paper was published in Aging (listed as "Aging (Albany NY)" by Medline/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 17, entitled, “Aging, …

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Aging | Extracellular microRNA and Cognitive Function in a Prospective Cohort of Older Men: The Veterans Affairs Normative Aging Study

09-15-2022

"As the U.S. population ages, there is growing concern about the loss of mental acuity associated with aging.”

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BUFFALO, NY- September 15, 2022 – A new research paper was published on the cover of Aging (listed as "Aging (Albany NY)" by Medline/PubMed and "Aging-US" by …

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Aging | Systemic Lipolysis Promotes Physiological Fitness in Drosophila Melanogaster

09-06-2022

A new research paper was published in Aging Volume 14, Issue 16, entitled, “Systemic lipolysis promotes physiological fitness in Drosophila melanogaster.”

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BUFFALO, NY- September 6, 2022 – A new research paper was published in Aging ("Aging (Albany NY)" by Medline/PubMed, …

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Aging | Synergism of BCL-2 Family Inhibitors Facilitates Selective Elimination of Senescent Cells

09-01-2022

A new research paper was published in Aging's Volume 14, Issue 16, entitled, “Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells.”

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BUFFALO, NY- September 1, 2022 – A new research paper was published in Aging ("Aging (Albany NY)" by …

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Aging | New Research: Volume 14, Issue 15

08-15-2022

BUFFALO, NY- August 15, 2022 – Aging (abbreviated as "Aging (Albany NY)" by Medline/PubMed and "Aging-US" by Web of Science) published a new issue of the latest research on aging in Volume 14, Issue 15. Publication titles, in addition to the associated researchers, are listed below.

Cover (Research Paper): Profiles of …

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Aging | Common Electrocardiogram Measures Are Not Associated With Telomere Length

08-10-2022

“Despite a known age-dependence of the ECG measures, we found no effect of telomere length beyond the influence of calendar age.”

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BUFFALO, NY- August 10, 2022 – A new research paper was published in Aging ("Aging (Albany NY)" by Medline/PubMed, "Aging-US" by Web of …

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Aging | Aging the Brain: Multi-region Methylation Principal Component Based Clock in the Context of Alzheimer’s Disease

08-01-2022

“PCBrainAge may aid in future investigations linking heterogeneity in the aging process to AD [Alzheimer’s disease] risk and individual resilience.”

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BUFFALO, NY- August 1, 2022 – A new research paper was published in Aging (abbreviated as "Aging (Albany NY)" by …

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Aging | Age-related Neuroendocrine, Cognitive, and Behavioral Co-morbidities Promoted by HIV-1 Tat Expression in Male Mice

07-28-2022

“The current work provides potentially actionable information that could help to limit premature or accentuated aging in the context of HIV.”

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BUFFALO, NY- July 28, 2022 – A new research paper was published in Aging (Aging-US / Albany NY)’s Volume 14, Issue 13, entitled, …

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Aging | Epigenetic Clocks and Their Association with Perceived Discrimination and Depressive Symptoms

07-18-2022

“To our knowledge, our study is among a few to systematically examine perceived discrimination in relation to epigenetic aging.”

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BUFFALO, NY- July 18, 2022 – A new research paper was published in Aging (Aging-US / Albany NY) on the cover of Volume 14, Issue 13, entitled, …

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Aging-US | Time Makes Histone H3 Modifications Drift in Mouse Liver

06-30-2022

“The comparison of different age profiles of histone H3 marks revealed global redistribution of histone H3 modifications with time […]”

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BUFFALO, NY- June 30, 2022 – A new research paper was published in Aging (Aging-US) on the cover of Volume 14, Issue 12, entitled, “Time…

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Aging's Latest Impact Factor (2021)

06-29-2022

Aging is pleased to report that our 2021 impact factor is 5.955.

BUFFALO, NY- June 29, 2022 – Aging is indexed by Web of Science: Science Citation Index Expanded (abbreviated as Aging‑US). As of June 29, 2022, Web of Science (Clarivate Analytics) released their 2021 JCR Impact Factor List. Aging is pleased to report …

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Aging (Aging-US) and FOXO Present: The Longevity & Aging Series

06-22-2022

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BUFFALO, NY- June 22, 2022 – Aging (Aging-US) and FOXO Technologies have teamed up to present a special collaboration on aging research with a new monthly video series: the Longevity & Aging Series. This series of video interviews invites Aging researchers to speak with …

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Aging (Aging-US) Sponsors 2022 NAD + Metabolism and Signaling Conference

06-21-2022

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BUFFALO, NY- June 21, 2022 – Aging (Aging-US) is proud to sponsor this year’s NAD + Metabolism and Signaling Conference (#NBCSRC22). This science research conference will take place from June 26 to June 30, 2022, in Steamboat Springs, Colorado, United States.

A coenzyme …

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Aging-US | WRNing for the Right DNA Repair Pathway Choice

06-16-2022

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BUFFALO, NY- June 16, 2022 – A new editorial paper was published in Aging (Aging-US) Volume 14, Issue 11, entitled, “WRNing for the right DNA repair pathway choice.”

Premature aging diseases, also called ‘progeroid syndrome’, display signs and features of normal aging in …

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Aging-US | Impact Journals Sponsors 2022 Ride for Roswell

06-14-2022

Impact Journals is sponsoring Team Open Access in the annual cycling event to end cancer: The Ride for Roswell. This fundraiser is hosted by Roswell Park Comprehensive Cancer Center in Buffalo, New York.

 

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BUFFALO, NY- June 14, 2022 – The Ride for Roswell is one of the …

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Aging-US | A Novel Discovery in Age-Related Macular Degeneration (AMD)

05-31-2022

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BUFFALO, NY- May 31, 2022 – A new research paper was published in Aging (Aging-US) on the cover of Volume 14, Issue 10, entitled, “Effect of Humanin G (HNG) on inflammation in age-related macular degeneration (AMD).”

Inflammatory processes drive the progression of …

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Aging (Aging-US) Sponsors Systems Aging Gordon Research Conference

05-24-2022

BUFFALO, NY- May 24, 2022 – Aging (Aging-US) is sponsoring the Systems Aging Gordon Research Conference, “Systemic Processes, Omics Approaches and Biomarkers in Aging,” from May 29 to June 3, 2022, at the Grand Summit Hotel at Sunday River in Newry, Maine, USA.


This year, the Chair and Vice Chair of the conference are …

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Aging-US: Hallmarks of Cancer and Hallmarks of Aging

05-18-2022

BUFFALO, NY- May 18, 2022 – Dr. Mikhail Blagosklonny published his new review paper in Aging (Aging-US) Volume 14, Issue 9, entitled, “Hallmarks of cancer and hallmarks of aging.”


In this review, Dr. Blagosklonny expands on Gems and de Magalhães' notion that canonic hallmarks of aging are superficial imitations of the …

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Impact Journals to Present Scientific Integrity Process at 2022 SSP Annual Meeting

05-16-2022

BUFFALO, NY-May 16, 2022 – Impact Journals (based out of Buffalo, New York) is an international open-access publisher of journals in the field of biomedical sciences. Impact Journals is on a mission to provide scientists with the opportunity to share exceptional discoveries, offer services that enable rapid …

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Altos Labs and the Quest for Immortality: Dr. Blagosklonny’s Perspective

05-11-2022

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BUFFALO, NY- May 11, 2022 – A new research perspective was published in Oncoscience journal by Mikhail Blagosklonny, M.D., Ph.D., entitled, "Altos Labs and the quest for immortality: but can we live longer right now?

“Here I discuss how combining rapamycin with other …

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Impact Journals at AACR Annual Meeting 2022

03-28-2022

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Impact Journals publishes scholarly journals in biomedical sciences with a focus on all areas of cancer and aging research. Impact Journals will be participating as an exhibitor at the American Association for Cancer Research (AACR) 2022 annual meeting from April 8-13, 2022, in New Orleans, Louisiana. This year, the AACR conference is entitled, “Decoding Cancer Complexity | Integrating Science | Transforming Patient Outcomes.”

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​​Aging-US: DNA methylation-based measures of biological age

01-03-2022

Aging-US published "DNA methylation-based measures of biological age: meta-analysis predicting time to death" which reported that estimates of biological age based on DNA methylation patterns, often referred to as "epigenetic age", "DNAm age", have been shown to be robust biomarkers of age in humans.

These authors …

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Aging-US: Epigenetic age of the pre-frontal cortex

01-03-2022

Aging-US published "Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning" which reported that there is an urgent need to develop molecular biomarkers of brain age in order to advance our understanding of age related …

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Aging-US: UBB+1 reduces amyloid-β cytotoxicity by activation of autophagy

12-20-2021

Aging-US published "UBB+1 reduces amyloid-β cytotoxicity by activation of autophagy in yeast" which reported that in their previous study, these authors found that yeast cells expressing UBB 1 at lower level display an increased resistance to cellular stresses under conditions of chronological aging.

In order to …

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Aging-US: Mitochondrial homeostasis in C. elegans model of human tauopathy

12-20-2021

Aging-US published "Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy" which reported however, whether mitochondrial dysfunction occurs prior to the detection of tau aggregates in tauopathies remains elusive.

Here, the authors utilized transgenic nematodes expressing …

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​​Aging-US: Early elevation of BACE1 in dementia

12-20-2021

Aging-US published "Early elevation of BACE1 in dementia" which reported that interest in the role of Beta-secretase1 in Alzheimer’s disease pathogenesis and patho- physiology has been remarkably growing in the last 10 years.

This transmembrane aspartyl protease catalyzes the rate-limiting step of the sequential …

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Aging-US: Effects of estradiol on biological age measured using the glycan age index

11-01-2021

Aging-US published "Effects of estradiol on biological age measured using the glycan age index" which reported that glycan age is a recently developed biomarker based on glycans attached to immunoglobulin G.

In large population cohorts, glycan age associates well with lifestyle and disease-risk biomarkers, while some …

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Aging-US: Cerebrovascular abnormalities in Alzheimer’s disease: adrenergic approach

10-25-2021

Aging-US published "Involvement of cerebrovascular abnormalities in the pathogenesis and progression of Alzheimer’s disease: an adrenergic approach" which reported that alzheimer’s disease, as the most common neurodegenerative disease in elder population, is pathologically characterized by β-amyloid plaques, …

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Aging-US: The key for anti-aging: calorie intake vs food quantity

10-25-2021

Aging-US published "Calorie intake rather than food quantity consumed is the key factor for the anti-aging effect of calorie restriction" which reported that although calorie restriction has been reported to extend lifespan in several organisms, animals subjected to calorie restriction consume not only fewer calories …

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Aging-US: Alleviating vascular dysfunction & amyloid burden in Alzheimer’s

10-25-2021

Aging-US published "Hyperbaric oxygen therapy alleviates vascular dysfunction and amyloid burden in an Alzheimer’s disease mouse model and in elderly patients" which reported that In the current study, the authors exposed 5XFAD mice, a well-studied AD model that presents impaired cognitive abilities, to HBOT and then …

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Aging-US: Deductive reasoning & principles of particle physics applied to aging research

10-25-2021

Aging-US published "Applying deductive reasoning and the principles of particle physics to aging research" which reported that aging research currently lacks a common conceptual framework, and one challenge in establishing it is the fact that aging is a highly complex process.

To help develop a framework of standard …

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Aging-US: Helicobacter pylori infection and risk for developing dementia

10-25-2021

Aging-US published "Helicobacter pylori infection and risk for developing dementia: an evidence-based meta-analysis of case-control and cohort studies" which reported that infection with multiple pathogens may play a key role in the pathogenesis of dementia.

Whether Helicobacter pylori infection is associated …

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Aging-US: A systemic multidisciplinary approach to study aging in sled dogs

10-25-2021

Aging-US published "Development of infrastructure for a systemic multidisciplinary approach to study aging in retired sled dogs" which reported that canines represent a valuable model for mammalian aging studies as large animals with short lifespans, allowing longitudinal analyses within a reasonable time frame.

Moreo…

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Aging-US: Iron: an underrated factor in aging

10-25-2021

Aging-US published "Iron: an underrated factor in aging" which reported that iron is an essential element for virtually all living organisms, but its reactivity also makes it potentially harmful. Blocking iron absorption through drugs or natural products extends lifespan.

Dr. Dennis Mangan from MTOR LLC in …

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Aging-US: Green tea catechins enhance fitness and lifespan of Caenorhabditis elegans

10-25-2021

Aging-US published "Green tea catechins EGCG and ECG enhance the fitness and lifespan of Caenorhabditis elegans by complex I inhibition" which reported that green tea catechins are associated with a delay in aging. The authors have designed the current study to investigate the impact and to unveil the target of the …

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Aging-US: Cellular senescence in lymphoid organs and immunosenescence

09-21-2021

Aging-US published "Cellular senescence in lymphoid organs and immunosenescence" which reported that immunosenescence is a multi-faceted phenomenon at the root of age-associated immune dysfunction.

Though both cellular senescence and immunosenescence have been studied extensively and implicated in various …

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Aging-US: The role of age at menarche and age at menopause in Alzheimer’s disease

09-21-2021

Aging-US published "The role of age at menarche and age at menopause in Alzheimer’s disease: evidence from a bidirectional mendelian randomization study" which reported that the association between endogenous estrogen exposure and Alzheimer’s disease remains inconclusive in previous observational studies, and few …

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Aging-US: Senescence-associated hyper-activation to inflammatory stimuli in vitro

09-21-2021

Aging-US published "Senescence-associated hyper-activation to inflammatory stimuli in vitro" which reported that aging is associated with an increased susceptibility to adverse inflammatory conditions such as sepsis and cytokine storm.

To test this hypothesis, the authors examined the expression of various …

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Aging-US: N6-methyladenosine and its clinical relevance in cognitive dysfunctions

09-21-2021

Aging-US published "N6-methyladenosine (m6A) modification and its clinical relevance in cognitive dysfunctions" which reported that the authors systematically investigated the molecular alterations of m6A regulators and their clinical relevance with cognitive dysfunctions using published datasets of Alzheimer's …

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​​​​​​Aging-US: Neurodegeneration in subjective cognitive decline

09-21-2021

Aging-US published "The interplay between gray matter and white matter neurodegeneration in subjective cognitive decline" which reported that subjective cognitive complaints were assessed through 9 questions covering amnestic and non-amnestic cognitive domains. In these author’s cohort, 123 individuals endorsed from …

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​​​​​​Aging-US: Reduced uremic metabolites are prominent feature of sarcopenia

09-21-2021

Aging-US published "Reduced uremic metabolites are prominent feature of sarcopenia, distinct from antioxidative markers for frailty" which reported that due to global aging, frailty and sarcopenia are increasing.

Sarcopenia is defined as loss of volume and strength of skeletal muscle in elderlies, while frailty …

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Aging-US: Age-related changes in eye lens biomechanics

09-08-2021

Aging-US published a Special Collection on Eye Disease which included "Age-related changes in eye lens biomechanics, morphology, refractive index and transparency" which reported that life-long eye lens function requires an appropriate gradient refractive index, biomechanical integrity and transparency.

The authors …

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Aging-US: Role of Citicoline in an in vitro AMD model

09-08-2021

Aging-US published a Special Collection on Eye Disease which included "Role of Citicoline in an in vitro AMD model" which reported that citicoline is the exogenous form of the nootropic, Cytidine 5'-diphosphate-choline that exerts its neuroprotective effects in the brain as well as in the eye.

Citicoline alleviates …

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Aging-US: PU-91 drug rescues human age-related macular degeneration cells

09-08-2021

Aging-US published a Special Collection on Eye Disease which included "PU-91 drug rescues human age-related macular degeneration RPE cells; implications for AMD therapeutics" which reported that the PU-91 drug upregulates PGC-1α which is a critical regulator of mitochondrial biogenesis.

Since mitochondrial …

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​​Aging-US: Nutraceutical effects of Emblica officinalis

09-08-2021

Aging-US published a Special Collection on Eye Disease which included "Nutraceutical effects of Emblica officinalis in age-related macular degeneration" which reported that EO has been used extensively as a nutraceutical in several diseases since it is known to boost immunity and offers numerous health benefits such …

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​​Aging-US: p62/SQSTM1 coding plasmid prevents age related macular degeneration

09-08-2021

Aging-US published a Special Collection on Eye Disease which included "p62 /SQSTM1 coding plasmid prevents age related macular degeneration in a rat model" which reported that P62/SQSTM1, a multi-domain protein that regulates inflammation, apoptosis, and autophagy, has been linked to age-related pathologies.

In …

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​​Aging-US: Loss of NAMPT in aging retinal pigment epithelium

09-08-2021

Aging-US published a Special Collection on Eye Disease which included "Loss of NAMPT in aging retinal pigment epithelium reduces NAD+ availability and promotes cellular senescence" which reported that retinal pigment epithelium performs numerous functions critical to retinal health and visual function.

Here, the …

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Aging-US: miR-106b suppresses pathological retinal angiogenesis

09-08-2021

Aging-US published a Special Collection on Eye Disease which included "miR-106b suppresses pathological retinal angiogenesis" which reported that microRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression.

Here, the authors show that expression of the miR-106b-25 cluster is negatively …

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Aging-US: Suppressing endoplasmic reticulum stress-related autophagy

09-08-2021

Aging-US published a Special Collection on Eye Disease which included "Suppressing endoplasmic reticulum stress-related autophagy attenuates retinal light injury" which reported that in this study, oxidative stress, endoplasmic reticulum stress and autophagy caused by light exposure were evaluated in vitro and in …

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Aging-US: RPE cell senescence in age-related macular degeneration

09-08-2021

Aging-US published a Special Collection on Eye Disease which included "HMGB1 and Caveolin-1 related to RPE cell senescence in age-related macular degeneration" and reported that AMD is a major unmet medical need as it is estimated that more than 20 million patients will be affected by 2050 in the US alone.

STGD is …

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Aging-US: 181 reported CHST6 variants in patients with macular corneal dystrophy

09-08-2021

Aging-US published a Special Collection on Eye Disease which included "A comprehensive evaluation of 181 reported CHST6 variants in patients with macular corneal dystrophy" which reported that macular corneal dystrophy is an autosomal recessive disease featured by bilateral progressive stromal clouding and loss of …

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Aging-US: Mitochondrial dysfunction and the effects of resveratrol in zebrafish

09-08-2021

Aging-US published a Special Collection on Eye Disease which included "Exploration of age-related mitochondrial dysfunction and the anti-aging effects of resveratrol in zebrafish retina" which reported that resveratrol was shown to not only increase mitochondrial quality and function, but also to suppress Akt/mTOR …

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​​Aging-US: Involvement of adiponectin in age-related increases in tear production

09-08-2021

Aging-US published a Special Collection on Eye Disease which included "Involvement of adiponectin in age-related increases in tear production in mice" which reported that the infiltration of lymphocytes into the lacrimal glands occurs with age, and age-related increases in tear production have also been observed in …

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​​​​Aging-US: Demethylation of FOXM1 mRNA promotes progression of uveal melanoma

09-08-2021

Aging-US published a Special Collection on Eye Disease which included "ALKBH5-mediated m6A demethylation of FOXM1 mRNA promotes progression of uveal melanoma" which reported that ALKBH5, a key component of the N6-methyladenosine (m6A) methyltransferase complex, was significantly elevated in uveal melanoma cell lines …

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​​​​​​Aging-US: An immune subtype of uveal melanoma with a poor prognosis

09-08-2021

Aging-US published a Special Collection on Eye Disease which included "Immunological analyses reveal an immune subtype of uveal melanoma with a poor prognosis" which reported that uveal melanoma is an aggressive intraocular malignancy that often exhibits low immunogenicity.

Metastatic uveal Melanoma samples …

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Aging-US: Exosomes attenuate ischemic retinal injury in vitro and in vivo

09-08-2021

Aging-US published a Special Collection on Eye Disease which included "Exosomes derived from BDNF-expressing 293T attenuate ischemic retinal injury in vitro and in vivo" which reported that this study investigated whether exosomes derived from BDNF-expressing 293T cells can be internalized by ischemic retinal cells …

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Aging’s Latest Impact Factor

08-22-2021

BUFFALO, NY-August 20, 2021Aging is indexed by Web of Science: Science Citation Index Expanded (abbreviated as Aging‑US). In June 2021, Web of Science (Clarivate Analytics) released their 2020 JCR Impact Factor. Aging is pleased to report that our 2020 impact factor is 5.682. This number has increased from last …

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Aging-US: Acid ceramidase promotes senescent cell survival

08-09-2021

Aging-US published “Acid ceramidase promotes senescent cell survival” which reported that the authors identified acid ceramidase (ASAH1), a lysosomal enzyme that cleaves ceramide into sphingosine and fatty acid, as being highly elevated in senescent cells.

This increase in ASAH1 levels in senescence is associated …

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Aging-US: A model of the aged lung epithelium in idiopathic pulmonary fibrosis

08-09-2021

Aging-US published "A model of the aged lung epithelium in idiopathic pulmonary fibrosis" which reported that Iiopathic pulmonary fibrosis (IPF) is an age-related disorder that carries a universally poor prognosis. By exposing mouse alveolar epithelial cells to repeated, low doses of bleomycin, instead of usual …

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Aging-US: PTEN nuclear translocation enhances neuronal injury after hypoxia-ischemia

07-25-2021

Aging-US published "PTEN nuclear translocation enhances neuronal injury after hypoxia-ischemia via modulation of the nuclear factor-κB signaling pathway" which reported that this study was designed to investigate phosphatase and tensin homolog nuclear translocation and its possible role in rat cortical neuronal …

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Aging-US: Hub candidate network for hepatocellular carcinoma

07-25-2021

Aging-US published "Identification of RNA binding protein interacting with circular RNA and hub candidate network for hepatocellular carcinoma" which reported that 17 DERBPs, which were commonly dysregulated in HCC from The Clinical Proteomic Tumor Analysis Consortium, The Cancer Genome Atlas and International Cancer …

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Aging-US: MiR-513b-5p represses autophagy by targeting PIK3R3

07-25-2021

Aging-US published "MiR-513b-5p represses autophagy during the malignant progression of hepatocellular carcinoma by targeting PIK3R3" which reported MiR-513b-5p repressed liver cancer cell proliferation, migration/invasion, and induced apoptosis in vitro.

Crucially, miR-513b-5p attenuated tumor growth of liver cancer …

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Aging-US: Modulating cancer cell responses during drug-induced senescence

07-25-2021

Aging-US published "The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence" which reported that cellular senescence may be a side effect of chemotherapy and other anti-cancer treatments that may promote inflammation and paracrine secondary senescence in healthy tissues.

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Aging-US: miRNAs generated from Meg3-Mirg locus are downregulated during aging

07-25-2021

Aging-US published "miRNAs generated from Meg3-Mirg locus are downregulated during aging" which reported that Aging determines a multilevel functional decline and increases the risk for cardiovascular pathologies.

The heart is one of the most affected organs in aged individuals, however little is known about the …

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Aging-US: Inducing apoptosis and enhancing cytoprotective autophagy in colon cancer

07-25-2021

Aging-US published "Antrodia salmonea induces apoptosis and enhances cytoprotective autophagy in colon cancer cells" which reported that 3- -2,5-diphenyltetrazolium bromide assay revealed that AS showed a remarkable effect on cell viability in colon cancer cells; SW620, HCT116, and HT29. Annexin V/propidium iodide …

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Aging-US: Calycosin inhibits breast cancer cell migration and invasion

07-25-2021

Aging-US published "Calycosin inhibits breast cancer cell migration and invasion by suppressing EMT via BATF/TGF-β1" which reported that in this study, the authors investigated the effects of calycosin on breast cancer cell progression and their underlying mechanisms. Calycosin dose- and time-dependently inhibited …

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Aging-US: Biomarkers of biochemical recurrence in prostate adenocarcinoma

07-25-2021

Aging-US published "Identification of microenvironment related potential biomarkers of biochemical recurrence at 3 years after prostatectomy in prostate adenocarcinoma" which reported that the authors aimed to identify the potential prognostic genes in the prostate adenocarcinoma microenvironment and to estimate the …

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Aging-US: HMGA1 promotes gastric cancer growth and metastasis

07-25-2021

Aging-US published "HMGA1 promotes gastric cancer growth and metastasis by transactivating SUZ12 and CCDC43 expression" which reported that HMGA1 is overexpressed in GC cells and the high expression of HMGA1 was correlated with worse survival in GC patients using a bioinformatics assay.

Functionally, HMGA1 affected …

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Aging-US: PirB functions as an intrinsic suppressor in hippocampal neural stem cells

07-25-2021

Aging-US published "PirB functions as an intrinsic suppressor in hippocampal neural stem cells" which reported that neural stem cells play pivotal roles during prenatal development and throughout life.

PirB expression increased with age during development, and its deficiency promoted neural stem cell proliferation …

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Aging-US: Responses of neurons, astrocytes, & microglia to G-quadruplex stabilization

07-25-2021

Aging-US published "Differential responses of neurons, astrocytes, and microglia to G-quadruplex stabilization" which reported that while it is now firmly established that stabilized G4s lead to enhanced genomic instability in cancer cells, whether and how G4s contribute to genomic instability in brain cells is still …

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Aging-US: Cognition and action: Executive functions to motor control in older adults

07-25-2021

Aging-US published "Cognition and action: a latent variable approach to study contributions of executive functions to motor control in older adults" which reported that Aging is associated with profound alterations in motor control that may be exacerbated by age-related executive functioning decline.

However, …

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Aging-US: High-calorie diet before calorie restriction on skeletal muscles

07-25-2021

Aging-US published "A novel ferroptosis-related gene signature for prognostic prediction of patients with lung adenocarcinoma" which reported that RNA-seq transcriptome data of LUAD patients were obtained from The Cancer Genome Atlas database.

Kaplan–Meier survival and receiver operating characteristic curves were …

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Aging-US: Prognostic prediction of patients with lung adenocarcinoma

07-25-2021

Aging-US published "A novel ferroptosis-related gene signature for prognostic prediction of patients with lung adenocarcinoma" which reported that RNA-seq transcriptome data of LUAD patients were obtained from The Cancer Genome Atlas database.

Kaplan–Meier survival and receiver operating characteristic curves were …

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Aging: Cdkn1a transcript Variant 2 is a Marker of Aging and Cellular Senescence

06-01-2021

Aging published "Cdkn1a transcript variant 2 is a marker of aging and cellular senescence" which reported that cellular senescence is a cell fate response characterized by a permanent cell cycle arrest driven primarily the by cell cycle inhibitor and tumor suppressor proteins p16Ink4a and p21Cip1/Waf1. In mice, the …

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Three years younger in just eight weeks? A new study suggests yes!

05-27-2021

A groundbreaking clinical trial shows we can reduce biological age (as measured by the Horvath 2013 DNAmAge clock) by more than three years in only eight weeks with diet and lifestyle through balancing DNA methylation.

A first-of-its-kind, peer-reviewed study provides scientific evidence that lifestyle and diet …

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Aging: Clinical Trial on Potential reversal of Epigenetic Age using a Diet and Lifestyle

05-27-2021

Aging published "Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial" which reported on a randomized controlled clinical trial conducted among 43 healthy adult males between the ages of 50-72. The 8-week treatment program included diet, sleep, exercise and …

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Aging-US: Aging phenotype of MDPL syndrome associated with impaired DNA repair capacity

03-15-2021

Aging-US published "Functional analysis of POLD1 p.ser605del variant: the aging phenotype of MDPL syndrome is associated with an impaired DNA repair capacity" which reported that Mandibular hypoplasia, Deafness and Progeroid features with concomitant Lipodystrophy define a rare systemic disorder, named MDPL Syndrome, …

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Aging-US: Aging and rejuvenation - a modular epigenome model

03-15-2021

Aging-US published "Aging and rejuvenation - a modular epigenome model" which reported that the view of aging has evolved in parallel with the advances in biomedical sciences.

Long considered as an irreversible process where interventions were only aimed at slowing down its progression, breakthrough discoveries like …

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Aging-US: High-CBD Cannabis sativa extracts modulate ACE2 expression in COVID-19

02-17-2021

Aging-US published "In search of preventive strategies: novel high-CBD Cannabis sativa extracts modulate ACE2 expression in COVID-19 gateway tissues" which reported that Cannabis sativa, especially those high in the anti-inflammatory cannabinoid cannabidiol, has been found to alter gene expression and inflammation …

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Aging-US: DNA- and telomere-damage does not limit lifespan: evidence from rapamycin

02-17-2021

Aging-US published "DNA- and telomere-damage does not limit lifespan: evidence from rapamycin" which reported that failure of rapamycin to extend lifespan in DNA repair mutant and telomerase-knockout mice, while extending lifespan in normal mice, indicates that neither DNA damage nor telomere shortening limits normal …

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Aging-US: Sulforaphane promotes C. elegans longevity and healthspan

02-02-2021

Aging-US published "Sulforaphane promotes C. elegans longevity and healthspan via DAF- 16/DAF-2 insulin/IGF-1 signaling" which reported that the broccoli-derived isothiocyanate sulforaphane inhibits inflammation, oxidative stress and cancer, but its effect on healthspan and longevity are unclear.

The authors used the …

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Aging-US: Screening Alzheimer’s disease by facial complexion using artificial intelligence

02-02-2021

Aging-US published "Screening of Alzheimer’s disease by facial complexion using artificial intelligence" which reported that despite the increasing incidence and high morbidity associated with dementia, a simple, non-invasive, and inexpensive method of screening for dementia is yet to be discovered.

This study aimed …

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Aging-US: Anserine protected against cognitive decline

02-02-2021

Aging-US published "Anserine, HClO-scavenger, protected against cognitive decline in individuals with mild cognitive impairment" which reported that In this study, the authors aimed to evaluate the effects of anserine, a scavenger of HClO, on the protection of cognitive declines in persons with MCI.

Fifty-eight …

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Aging-US: A pro-diabetogenic mtDNA polymorphism in mitochondrial-derived peptide

02-02-2021

Aging-US published "A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c" which reported that although ethnic specific mtDNA polymorphisms have been shown to contribute to T2D risk, the functional effects of the mtDNA polymorphisms and the therapeutic potential of mitochondrial-derived …

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Aging-US: PAM (PIK3/AKT/mTOR) signaling in glia: potential contributions to brain tumors

01-19-2021

Aging-US Issue 1 Volume 13 features "PAM (PIK3/AKT/mTOR) signaling in glia: potential contributions to brain tumors in aging" which reported that despite a growing proportion of aged individuals at risk for developing cancer in the brain, the prognosis for these conditions remains abnormally poor due to limited …

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Aging-US: Knockdown of TXNDC9 induces apoptosis and autophagy in glioma

11-13-2020

Aging-US recently published "Knockdown of TXNDC9 induces apoptosis and autophagy in glioma and mediates cell differentiation by p53 activation" which reported that no research associated with TXNDC9 has been reported in glioma.

In this study, the found that TXNDC9 was upregulated in glioma.

Knockdown of TXNDC9 would …

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Aging-US: Alzheimer’s disease as a systems network disorder

11-13-2020

Aging-US recently published "Alzheimer’s disease as a systems network disorder: chronic stress/dyshomeostasis, innate immunity, and genetics" which reported that ineffective results of clinical trials of over 200 anti-Alzheimer's drug candidates, with a 99.6% attrition rate, suggest that the current paradigm of …

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Aging-US: MiR-520d-5p modulates chondrogenesis and chondrocyte metabolism through targeting HDAC1

11-10-2020

Aging-US recently published "MiR-520d-5p modulates chondrogenesis and chondrocyte metabolism through targeting HDAC1" which reported that this study aimed to determine miRNAs associated with chondrogenesis of human mesenchymal stem cells and chondrocyte metabolism.

MiRNAs were screened in hMSCs during chondrogenesis …

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Aging-US: GPA peptide inhibits NLRP3 inflammasome activation to ameliorate colitis

11-10-2020

Aging-US recently published "GPA peptide inhibits NLRP3 inflammasome activation to ameliorate colitis through AMPK pathway" which reported that pyroptosis and NLRP3 inflammasome are associated with various kinds of inflammatory diseases including colitis.

In vivo, the authors found GPA peptide could exert …

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Aging-US: Psychological aging, depression, and well-being

11-10-2020

Aging-US recently published "Psychological aging, depression, and well-being" which reported that Aging is a multifactorial process, which affects the human body on every level and results in both biological and psychological changes.

These factors can be used for a future development of individual psychological …

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Aging-US: Characterization of LncRNA SNHG22 as a protector of NKIRAS2

11-10-2020

Aging-US recently published "Characterization of LncRNA SNHG22 as a protector of NKIRAS2 through miR-4492 binding in osteosarcoma\” which reported that the underlying mechanism of SNHG22 in regulating OS progression remains unknown.

In this study, the authors confirmed that SNHG22 was downregulated in OS, and the …

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Aging-US: From causes of aging to death from COVID-19

10-05-2020

Aging-US recently published "From Causes of Aging to Death from COVID-19" by Blagosklonny et al. which reported that COVID-19 is not deadly early in life, but mortality increases exponentially with age - which is the strongest predictor of mortality.

The Review covers:

  1. Age
  2. Age-related diseases
  3. Male Gender
  4. Mortality from …

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Aging-US: SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2

06-29-2020

The cover for issue 12 of Aging-US features "SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair" by Rezazadeh et al. and reported that when transcribed DNA is damaged, the transcription and DNA repair machinery must interact to ensure …

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Aging-US: COVID-19 and chronological aging: anti-aging drugs for treatment or prevention

04-20-2020

Volume 12, Issue 8 of @AgingJrnl reported that similarly, two proposed therapeutics for the treatment of COVID-19 infection are Azithromycin and Quercetin, both drugs with significant senolytic activity.

Therefore, the authors wish to speculate that the fight against COVID-19 disease should involve testing the …

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Scientist proposes clinical trials w/ low-dose rapamycin to protect elderly from COVID-19

04-03-2020

Friday, 3rd of April, 2020, London, UK - The Biogerontology Research Foundation, a registered UK charity supporting and promoting aging and longevity research worldwide since 2008, today announced the publication of a paper titled “Geroprotective and senoremediative strategies to reduce the comorbidity, infection …

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Female adipose tissue has improved adaptability and metabolic health compared to males in aged obesity

02-13-2020

Aging-US Volume 12, Issue 2 reported that Younger females are protected from adipose inflammation, but older post-menopausal females exhibit exaggerated visceral adiposity correlated with increased disease risk.

Obesity accelerates the onset and progression of age-associated diseases, but it is unclear if aging and …

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Resveratrol targets PD-L1 glycosylation and dimerization to enhance antitumor T-cell immunity

02-13-2020

The cover features Figure 9 "Resveratrol enhances antitumor T cell immunity by promoting abnormal glycosylation and dimerization of PD-L1." from Verdura et al..

RSV was also predicted to interact with the inner surface of PD-L1 involved in the interaction with PD-1, almost perfectly occupying the target space of the …

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Deep biomarkers of aging and longevity: from research to applications

12-03-2019

Deep biomarkers of aging and longevity: from research to applications

The deep age predictors can help advance aging research by establishing causal relationships in nonlinear systems.

Deep aging clocks can be used for identification of novel therapeutic targets, evaluating the efficacy of various interventions, data …

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Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy

11-18-2019

The cover features Figure 3 "Calculated bioenergetic health index (BHI) from young and old CD4+ T cells" from Bektas et al.

Though mitochondrial number in both naive and memory cells visualized with electron microcopy was similar in older versus younger participants, there were a significantly higher number of …

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Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development

11-05-2019

The cover features Figure 4 "SAMP8 mice display a spontaneous OA phenotype" from Malaise

The research team tests whether by becoming senescent, the mesenchymal stromal/stem cells, found in the synovial tissue and sub-chondral bone marrow, can contribute to OA development.

When co-cultured with OA chondrocytes, …

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Rapamycin for longevity- opinion article

10-14-2019

The scientist discusses several reasons, including fear of the actual and fictional side effects of rapamycin, everolimus and other clinically-approved drugs, arguing that no real side effects preclude their use as anti-aging drugs today.

They go on to discuss why it is more dangerous not to use anti-aging drugs than …

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Subunit contribution to NMDA receptor hypofunction and redox sensitivity of hippocampal synaptic transmission during aging

10-06-2019

The researchers examined the contribution of N-methyl-D-aspartate receptor subunits in the redox-mediated decline in NMDAR function during aging.

Glu N2A and Glu N2B selective antagonists decreased peak NMDAR currents to a similar extent in young and aged animals, indicating that a shift in diheteromeric Glu N2 …

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Conclusions from a behavioral aging study on male and female F2 hybrid mice on age-related behavior, buoyancy in water-based tests, and an ethical method to assess lifespan

10-05-2019

Due to strain-specific behavioral idiosyncrasies, inbred mouse strains are suboptimal research models for behavioral aging studies.

The researchers found that both males and females demonstrated decreased exploratory behavior with age, while memory and depressive-like behavior were maintained.

Dr. Malin Hernebring …

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Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation

10-04-2019

The researchers recruited healthy older participants to two groups according to their history of tea drinking frequency and investigated both functional and structural networks to reveal the role of tea drinking on brain organization.

The suppression of hemispheric asymmetry in the structural connectivity network was …

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Adipogenic progenitors keep muscle stem cells young

10-03-2019

In adult skeletal muscle, loss of myofiber integrity caused by mechanical injuries or diseases are repaired by resident muscle stem cells, called satellite cells, which promptly exit from quiescence after disruption of muscle architecture to expand, differentiate and drive tissue regeneration.

Dr. Jerome N. Feige …

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The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis

10-02-2019

Marrow adipose tissue expansion and associated lipotoxicity are important drivers of age-related bone loss and hematopoietic bone marrow atrophy.

Dr. Gustavo Duque from the Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, VIC, Australia and the …

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Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging

09-30-2019

For Aging’s Volume 11, Issue 18, the Journal devoted the Cover to a research paper by Dr. Alejandro Martin-Montalvo from the Department of Regeneration and Cell Therapy, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of …

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DNA methylation-based estimator of telomere length

08-25-2019

Leukocyte DNAm TL is applicable across the entire age spectrum and is more strongly associated with age than measured leukocyte TL.

Leukocyte DNAm TL outperforms LTL in predicting: i)time-to-death, ii)time-to-coronary heart disease, iii)time-to-congestive heart failure and iv)association with smoking history.

Dr. …

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Epigenome-wide association study of leukocyte telomere length

08-25-2019

In this study, the research team conducted a large-scale epigenome-wide association study of LTL using seven large cohorts the Framingham Heart Study, the Jackson Heart Study, the Womens Health Initiative, the Bogalusa Heart Study, the Lothian Birth Cohorts of 1921 and 1936, and the Longitudinal Study of Aging Danish …

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‘Tickle’ therapy could help slow ageing

07-30-2019

‘Tickling’ the ear with a small electrical current appears to rebalance the autonomic nervous system for over-55s, potentially slowing down one of the effects of ageing, according to new research.

Scientists found that a short daily therapy delivered for two weeks led to both physiological and wellbeing improvements, …

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Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation

06-04-2019

Cessation, or even retardation of the ageing process is an appealing notion that has captured the imagination of humans for millennia. Even if it were possible to rejuvenate our bodies or retard the ageing process, how do we measure this?

Age, as we know it, is clearly an inappropriate measurement because it is based …

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Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype

06-01-2018

The specific molecular mechanism of selective release and retention of senescence-associated sEV-mi RNAs and the EV-SASP cross talk between different cell types and its consequences in the context of aging and age-associated diseases, however, remains to be elucidated.

Dr. Johannes Grillari said "We confirm that EVs …

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DNA methylation GrimAge strongly predicts lifespan and healthspan

06-01-2018

The Grim Reaper arrives for each of us eventually—wouldn’t it be nice to know when? Now UCLA researchers have developed a new tool to help you plan ahead for your date with the Angel of Death.

Named after the grim reaper, the biomarker known as DNA methylation GrimAge, allows one to predict lifespan and …

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Sex differences in transcriptomic profiles in aged kidney cells of renin lineage (CoRL)

06-01-2018

The researchers found a small core set of genes involved in stemness, proliferation and migration that showed consistent changes with advanced age in cells of renin lineage (CoRL)within the kidney.

Surprisingly, most gene expression changes in CoRL aging are sex-specific: aged female mice showed up-regulation of …

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Exploiting mitochondrial targeting signal(s), TPP and bis‐TPP, for eradicating cancer stem cells (CSCs)

06-01-2018

TPP-related compounds may provide a novel chemical strategy for effectively targeting bulk cancer cells and CSCs, while minimizing off-target side-effects in normal cells.

Several independent lines of evidence support the idea that increased mitochondrial biogenesis or higher levels of mitochondrial protein …

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